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Pulmonary function in patients with inflammatory bowel disease.

O E Eade, C L Smith, J R Alexander

The American Journal of Gastroenterology

|February 1, 1980

Summary

Inflammatory bowel disease patients show reduced pulmonary function, specifically in carbon monoxide transfer factor. This lung impairment is significant compared to healthy individuals and not clearly linked to sulfasalazine treatment.

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Area of Science:

Pulmonology
Gastroenterology
Internal Medicine

Background:

Inflammatory bowel disease (IBD) encompasses chronic conditions affecting the gastrointestinal tract.
Extraintestinal manifestations of IBD, including pulmonary complications, are increasingly recognized.
Assessing pulmonary function in IBD patients is crucial for understanding disease impact.

Purpose of the Study:

To evaluate pulmonary function in outpatients diagnosed with inflammatory bowel disease.
To determine if specific lung function parameters are altered in IBD patients compared to controls.

Main Methods:

Pulmonary function tests were conducted on 36 outpatients with inflammatory bowel disease.
Carbon monoxide transfer factor (COTF) was measured.

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Results were compared against a matched control group.

Main Results:

A statistically significant reduction in carbon monoxide transfer factor was observed in IBD patients (P < 0.01).
The observed lung function impairment was notable when compared to healthy controls.

Conclusions:

Patients with inflammatory bowel disease exhibit impaired pulmonary function, indicated by reduced carbon monoxide transfer factor.
The precise cause of this pulmonary dysfunction remains undetermined.
Sulfasalazine (Salazosulphapyridine), a common IBD medication, is unlikely to be the primary reason for the observed lung function reduction.