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Mefenamic acid nephropathy.

C E Robertson, M J Ford, V Van Someren

    Lancet (London, England)
    |August 2, 1980
    PubMed
    Summary
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    Elderly women developed non-oliguric renal failure after taking mefenamic acid for musculoskeletal pain. This highlights a potential risk of non-steroidal anti-inflammatory drugs in older populations.

    Area of Science:

    • Nephrology
    • Pharmacology
    • Geriatrics

    Background:

    • Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain relief.
    • Elderly individuals may be more susceptible to adverse drug reactions.
    • Mefenamic acid is an NSAID used for mild to moderate pain.

    Purpose of the Study:

    • To report cases of non-oliguric renal failure in elderly women associated with mefenamic acid use.
    • To investigate the potential nephrotoxic effects of mefenamic acid in a specific patient demographic.

    Main Methods:

    • Retrospective case review of six elderly female patients.
    • Analysis of medication history, focusing on mefenamic acid dosage and duration.
    • Assessment of renal function parameters before and after drug exposure.

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    Main Results:

    • All six patients developed non-oliguric renal failure.
    • Patients were prescribed 1-2 g of mefenamic acid daily for 2-6 weeks.
    • Renal failure occurred in the context of musculoskeletal pain management.

    Conclusions:

    • Mefenamic acid may cause non-oliguric renal failure in elderly women.
    • Clinicians should exercise caution when prescribing mefenamic acid to older patients.
    • Further research is warranted to elucidate the mechanisms of NSAID-induced nephrotoxicity in the elderly.