Use of pentagastrin test as a combined teaching and research project for medical students

The pentagastrin acid-secretion test was used to teach medical students gastric investigation, the structure of a controlled trial, and the application of non-parametric statistics to the analysis of imperfect data. This teaching project also yielded considerable original data from 150 subjects on the extra-gastric effects of pentagastrin and histamine-receptor antagonists. Some, but not all, of the somatic symptoms induced by pentagastrin were abolished by cimetidine; however, the combination of pentagastrin and cimetidine induced a significant (p < 0.02) incidence of dizziness.