Alpha-adrenergic blocking agents and the cardiovascular response to pharmacological doses of vasopressin

The effects of alpha-adrenergic blockade with phentolamine or dibenamine on the cardiovascular response to pharmacological doses of vasopressin were studied in anesthetized dogs. Some observations were also made on the combined effects of vasopressin and norepinephrine. Changes in mean systemic arterial pressure, portal pressure, and resistance in the prehepatic splanchnic vasculature during vasopressin infusion were noted. A total of 97 dogs were used. alpha-Blockade appeared to enhance the response of arterial pressure to vasopressin, possibly because of loss of baroreceptor-mediated buffering action which normally attenuates its pressor action. Effects of vasopressin on mesenteric vascular resistance and portal pressure were unchanged or somewhat less after alpha-blockade, hence no evidence that its therapeutic effect would be improved by this combination. Vasopressin and norepinephrine when given together result in an additive pressor response with little or no evidence of potentiation.