Psychiatric implications of anticonvulsant drugs

The spectrum of contemporary antiepileptics are categorically reviewed with reference to adverse behavioral sequelae. These iatrogenic disturbances may have peripheral (eg. heptatic dysfunction, blood dyscrasia, or lupus-like syndromes) or central (eg. altered neurotransmission) manifestations. Whether an idiosyncratic reaction, toxic circumstance, or untoward drug interaction, there is scant understanding of the predisposing factors or recognition of the neuropsychiatric influence of anticonvulsant therapy.