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The adrenal androgen-stimulating hormone does not exist.

D C Anderson

    Lancet (London, England)
    |August 30, 1980
    PubMed
    Summary

    A newly proposed pituitary hormone stimulating adrenal androgen production, or adrenarche, likely does not exist. Instead, high cortisol levels locally induce changes in adrenal cells, explaining adrenarche development.

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    Area of Science:

    • Endocrinology
    • Adrenal Physiology
    • Pediatric Endocrinology

    Background:

    • The adrenarche, or adrenal androgen production increase during childhood, is traditionally attributed to a pituitary hormone.
    • This postulated hormone, acting alongside adrenocorticotrophic hormone (ACTH), remains unidentified, prompting alternative explanations.

    Purpose of the Study:

    • To challenge the existence of a separate pituitary cortical androgen-stimulating hormone.
    • To propose an alternative mechanism for adrenarche driven by local cortisol exposure.

    Main Methods:

    • Conceptual analysis and review of existing physiological data on adrenal function.
    • Hypothesizing a local induction mechanism for adrenarche based on cortisol dynamics.

    Main Results:

    • The study suggests that a distinct pituitary hormone for adrenarche is unnecessary.
    • Adrenarche is proposed to result from morphological and functional changes in the zona reticularis cells.
    • These changes are hypothesized to be induced by prolonged local exposure to high cortisol levels after ACTH stimulation.

    Conclusions:

    • The existence of a pituitary cortical androgen-stimulating hormone is unlikely.
    • Adrenarche can be explained by local cortisol effects on the zona reticularis, influenced by ACTH pulse dynamics.

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