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Biologically active peptides: prospects for drug development.

J Hughes

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
    |August 11, 1980
    PubMed
    Summary
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    Biologically active peptides play diverse roles in brain function, influencing mood, memory, and pain. Research explores their potential for drug development, particularly peptide antagonists for conditions like infertility.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Biochemistry

    Background:

    • Biologically active peptides are abundant, diverse, and bind with high affinity to receptors.
    • Recent discoveries include enkephalins, endorphins, vasoactive intestinal peptide, and neurotensin.
    • These peptides may be crucial for the chemical coding of brain functions like pain, mood, and memory.

    Purpose of the Study:

    • To explore the potential roles of newly discovered endogenous peptides in brain function.
    • To assess the current and future prospects for peptide-based drug development.

    Main Methods:

    • Review of current research on endogenous peptides and their functions.
    • Analysis of drug development strategies for peptide agonists and antagonists.
    • Consideration of rational drug design, natural product screening, and genetic engineering.

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    Main Results:

    • The role of many endogenous peptides in brain function is not yet clearly defined.
    • Peptide agonists show potential in analgesia and controlling pituitary and gastrointestinal functions.
    • Peptide antagonists offer broad future development potential, with LHRH antagonists for antifertility showing immediate promise.

    Conclusions:

    • Peptides represent a significant area for understanding brain function and developing novel therapeutics.
    • Rational drug design and screening of natural products are key industrial approaches.
    • Further research into peptide agonists and antagonists could lead to breakthroughs in medicine.