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Antiarrhythmic effects of four different beta-adrenergic blockers in the mouse chloroform arrhythmia model
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1980
Abstract:
The antiarrhythmic activity of four different beta-adrenergic blockers was assessed in the mouse chloroform arrhythmia model. ED50 values and 95% confidence intervals established by i.p. administration of drug were: propranolol (22.8, 10.9--67.0 mg/kg), sotalol (38.0, 15.9--58.5 mg/kg) and practolol (167, 111--235 mg/kg). Butoxamine provided some protection against the arrhythmia within a narrow dose range (53 to 79 mg/kg).