Phenylketonuria: the inadvisability of neuroleptic medication

The use of neuroleptic medications in two disturbed phenylketonuria patients was studied over a period between 4 to 5 years. The outcome of clinical observation, supported by the neurochemical findings, suggests that most neuroleptic medications may be less than indicated for treating these patients. The observation provides an important example of how an adverse neuroleptic drug response can be predicted by base-line biochemical measures which are closer to the basic pathophysiology of the condition and the site of psychotropic drug action.