Effects of structural variations of non-ionic surfactants on micellar properties and solubilization: surfactants...

Studies on erucyl alcohol ethoxylated with 24 units and on behenyl alcohol ethoxylated with 21 ethylene oxide units gave values of 10.2 x 10(3) and 25.4 x 10(3) for the micellar weights, 74 and 203 for the aggregation number, and 134 and 106 moles water mole-1 surfactant for the micellar hydration, respectively. The solubilization of azobenzene, cortisone acetate, griseofulvin, sulphadiazine, phenylbutazone, betamethasone, tolbutamide, and menaphthone was studied in 2% solutions of the above surfactants, and in cetomacrogol. Excluding sulphadiazine, a linear relationship was found between moles solubilized/mole surfactant, and (log P)/molar volume of solubilizate.