The effect of proteolytic enzymes on the disposition of tetracycline

The acute administration of a mixture of trypsin and chymotrypsin did not significantly affect the rate or extent of disappearance of tetracycline from the rat gut in situ, nor did chronic administration of enteric coated tablets containing trypsin and chymotrypsin to rats significantly influence the rate or extent of absorption of tetracycline compared with rats receiving enteric coated placebo tablets. Similarly, chronic enzyme administration did not effect either the systemic clearance, half life or apparent volume of distribution of intravenously administered tetracycline compared with rats receiving placebo tablets.