The potential of GABA-mimetics in the therapy of extrapyramidal disorders

GABA mimetics inhibit extrapyramidal DA and ACh neurons and affect an unknown system beyond both DA and ACh receptors, which is involved in extrapyramidal motor outputs. Based on these data, the rationale is discussed for the clinical use of GABA mimetics in Huntington's chorea, parkinsonian tremor, L-DOPA or neuroleptic-induced dyskinesias.