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Related Experiment Videos

Dimethylsulphoxide-induced toxicity.

P Yellowlees, C Greenfield, N McIntyre

    Lancet (London, England)
    |November 8, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Intravenous dimethylsulphoxide (DMSO) treatment for arthritis caused serious illness in one elderly patient, with both showing enzyme changes and red blood cell damage (hemolysis). This study highlights potential adverse effects of IV DMSO in humans.

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    Area of Science:

    • Biochemistry
    • Pharmacology
    • Geriatrics

    Background:

    • Dimethylsulphoxide (DMSO) is explored as a potential treatment for arthritis.
    • Intravenous administration of DMSO is being investigated for therapeutic effects.

    Observation:

    • Two elderly patients received intravenous DMSO for arthritis.
    • One patient experienced severe illness, while the other remained well.

    Findings:

    • Both patients exhibited elevated serum enzymes: aspartate transaminase (AST), hydroxybutyrate dehydrogenase (HBDH), and creatine kinase (CK).
    • Evidence of hemolysis (red blood cell breakdown) was observed in both individuals.
    • This marks the first documented report of serum enzyme alterations and anemia following intravenous DMSO administration in humans.

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    Implications:

    • Intravenous DMSO may pose risks, including potential liver and muscle damage, and hematological toxicity.
    • Further research is warranted to understand the safety profile and mechanisms of DMSO-induced toxicity.
    • Clinical use of intravenous DMSO requires careful patient monitoring for adverse effects.