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Related Experiment Videos

Human lymphomas transplanted in nude mice.

G Delsol, I Neulat, C Marty

    Virchows Archiv. B, Cell Pathology Including Molecular Pathology
    |January 1, 1980
    PubMed
    Summary

    Malignant lymphomas showed a low take rate (8.3%) when transplanted into nude mice. High-grade non-Hodgkin

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    Area of Science:

    • Oncology
    • Immunology
    • Virology

    Background:

    • Nude mice are frequently used as a model for human cancer research due to their immunodeficiency.
    • Understanding the engraftment potential of various lymphoma subtypes in xenograft models is crucial for preclinical studies.

    Purpose of the Study:

    • To determine the subcutaneous take rate of malignant lymphomas in nude mice.
    • To characterize the biological behavior and potential viral contamination of successful xenotransplants.

    Main Methods:

    • Subcutaneous transplantation of lymphoid tissue from patients with lymphoproliferative and lymphomatous disorders into nude mice.
    • Serial transfer of successful xenografts.
    • Histopathological and electron microscopic examination of tumors.
    • Detection of C-type retroviruses.

    Main Results:

    • A low overall take rate (8.3%) was observed for malignant lymphomas.
    • Four non-Hodgkin's lymphomas (lymphoplasmacytic, lymphoblastic, immunoblastic, centroblastic) engrafted successfully.
    • High-grade lymphomas demonstrated a higher propensity for engraftment compared to low-grade types.
    • Tumors in mice resembled patient tumors, with one case showing metastases.
    • Neoplastic cells were associated with unidentified dark cells, and C-type retroviral particles were detected in two cases.

    Conclusions:

    • Malignant lymphomas exhibit a limited capacity for subcutaneous engraftment in nude mice.
    • High-grade lymphomas are more amenable to xenotransplantation.
    • Xenotransplanted lymphomas can retain patient-like characteristics and may harbor viral contaminants.

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