Nuclear and nucleolar effect of experimental endotoxemia on rabbit hepatocytes

Nuclear and nucleolar ultrastructure was studied in hepatocytes of rabbits intravenously injected with a single dose of endotoxin to provide more information on the ultrastructural changes of hepatocytes produced by the endotoxemia. The observed changes were represented by a clumping of interchromatin granules, alteration of nucleolar architecture and formation of rodlet-like intranuclear inclusions. The alteration of the nucleolar architecture was characterized by loosely arranged rope-like nucleolonemata, partial retraction of the perinucleolar chromatin and increased numbers of fibrillar centers.