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Gastroenteropancreatic hormonal changes during exercise.

J Hilsted, H Galbo, B Sonne

    The American Journal of Physiology
    |September 1, 1980
    PubMed
    Summary
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    Exercise significantly alters key gastrointestinal hormones, increasing vasoactive intestinal polypeptide (VIP), secretin, pancreatic polypeptide (PP), and somatostatin (SRIF) while decreasing insulin and glucose levels. The precise roles of these hormonal shifts during physical activity remain unclear.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Exercise Physiology

    Background:

    • Gastroenteropancreatic (GEP) peptides play crucial roles in digestion and metabolism.
    • The impact of sustained moderate-intensity exercise on GEP peptide concentrations is not well-defined.
    • Understanding hormonal responses to exercise is vital for metabolic and physiological insights.

    Purpose of the Study:

    • To investigate the changes in peripheral plasma concentrations of various GEP peptides during prolonged bicycle exercise.
    • To assess the relationship between exercise and the secretion/clearance of insulin and C-peptide.
    • To determine the physiological role of these hormonal changes during physical exertion.

    Main Methods:

    • Six healthy men performed 3 hours of bicycle exercise at 40% of maximal oxygen uptake.

    Related Experiment Videos

  • Peripheral plasma concentrations of vasoactive intestinal polypeptide (VIP), secretin, pancreatic polypeptide (PP), somatostatin (SRIF), gastric inhibitory polypeptide, insulin, and C-peptide were measured.
  • Plasma glucose levels were also monitored throughout the exercise and rest periods.

    • Main Results:

    • Significant increases were observed in VIP, secretin, PP, and SRIF concentrations.
    • A notable decrease in plasma insulin and C-peptide levels was recorded, indicating reduced insulin secretion and clearance.
    • Plasma glucose levels decreased significantly, while gastric inhibitory polypeptide remained unchanged.

    Conclusions:

    • Moderate-intensity exercise induces substantial alterations in GEP peptide profiles.
    • The observed decrease in insulin and C-peptide suggests a complex regulation of glucose homeostasis during exercise.
    • The precise stimuli and physiological functions of exercise-induced VIP, secretin, PP, and SRIF require further investigation.