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Quantitative structure-activity relationship in 1-substituted ureidophenoxy-3-amino-2-propanols, a class of
Arzneimittel-Forschung
|January 1, 1980
Abstract:
The beta-adrenergic blocking potency of 56 1-substituted ureidophenoxy-3-amino-2-propanols has been analysed in terms of the linear Free-Wilson model. The values obtained for the Free-Wilson coefficients have been correlated with the chemico-physical parameters of the substituents. The preliminary indication given by the Free-Wilson analysis has been confirmed by a quantitative regression analysis, carried out in the frame of the "mixed approach" method.