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Updated: Aug 18, 2026

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder
Published on: July 7, 2023
[Configuration frequency analysis. XI. Strategies of symptom configuration comparison before and after therapy]
Abstract:
Four strategies are proposed for comparing patterns of yes-no-symptoms before and after therapy (or time elapsed) in a sample of N patients: 1) a test for change of (mean) symptom score, 2) a test for (proportional) change of a specified symptom, 3) a test for (proportional) change of a specified symptom pattern and 4) a test for specified change or persistence of a selected symptom pattern. All strategies are exemplified by N = 75 schizophrenics observed as to 3 main symptoms (emotional withdrawal, thinking disturbances, and hallucinations) before and after a neuroleptic treatment.
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