[Cholinergic antagonism by beta-blockers. I. Spectrum of interactions]

Complete final steady state selective antagonism by beta-blockers of different conventional classes versus acetylcholine effects on isolated frog rectus abdominis, guinea pig ileum and spontaneous beating auricles had been measured. The results do not support common beta-blockers groupings, nor binary conventional subdivision of "nicotinic" and "muscarinic" cholinergic receptors, confirming our previous findings.