[Effect of clofelin on brain bioelectrical activity]

The hypotensive drug clofelin, 2-(2,6-dichlorphenylamino)-2-imidazoline hydrochloride, which is similar to clonidin exerts a synchronous effect on EEG of cats and rabbits both intravenously and when instilled into the eye conjunctival sac. The synchronous effect of clofelin is reversed by iochimbine, decreased by phentolamine, tropaphen and piroxan, diminished by atropine and benactizin rather than by metacin, and is blocked by amphetamine. The effect of clofelin on the central alpha-adrenoreceptors and certain influence on the central cholinoreactive systems play an essential role in the mechanism of its sedative action.