[Characteristics of the anticonvulsant effects of fenazepam]

Studies of the new benzodiazepine drug phenazepam comparatively to diazepam, clonazepam, nitrazepam, phenobarbital and diphenylhydantoin have shown that by its anticonvulsant effects phenazepam is similar to clonazepam and differs from other antiepileptic agents. Phenazepam exhibits a pronounced capacity for removing paroxysmal epileptiform discharges induced by cobalt application to the surface of the brain cortex. Prolonged administration induces tolerance to phenazepam as shown by antagonism to strychnine and by capacity for preventing convulsions in maximal electric shock.