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Updated: Oct 24, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

[Assessment of lung function in asthmatic children during a stay on the North Sea coast (author's transl)]

H von der Hardt, W Menger

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |December 1, 1980
    PubMed

    Insights

    Asthmatic children showed larger lung volumes but lower dynamic lung compliance. Orciprenaline temporarily reduced airway resistance, suggesting small airway obstruction in pediatric asthma.

    Area of Science:

    • Pediatric Pulmonology
    • Respiratory Physiology
    • Asthma Research

    Context:

    • Study conducted on 40 asthmatic children during symptom-free periods on Norderney.
    • Lung function parameters including FRC, VC, TLC, R1, and C1dyn were measured.
    • Environmental factors of Norderney may influence results.

    Purpose:

    • To assess lung function in asthmatic children during symptom-free periods.
    • To evaluate the effect of Orciprenaline on lung function parameters.
    • To investigate potential causes of altered lung mechanics in pediatric asthma.

    Summary:

    • Asthmatic children exhibited significantly larger lung volumes and significantly lower dynamic lung compliance compared to predicted values.
    • Mean total pulmonary flow resistance was initially normal but decreased significantly after Orciprenaline inhalation.
    • Lung volumes and dynamic lung compliance remained unchanged post-inhalation, indicating a temporary effect on resistance.

    Impact:

    • Findings suggest small airway obstruction as a key factor in pediatric asthma, potentially independent of beta-2-mimetic drug effects.
    • Highlights the temporary bronchodilator response in asthmatic children's airway resistance.
    • Contributes to understanding the complex pathophysiology of asthma in children.

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