Influence of benzodiazepine tranquilizers on amphetamine-induced locomotor stimulation in mice

Four benzodiazepine tranquilizers have been tested, alone or in combination with amphetamine, on spontaneous locomotor activity of C57BL/6 mice. Amphetamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. The results indicate that benzodiazepine derivatives may be somewhat differentiated on the basis of their interactions with amphetamine.