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Is pseudomembranous colitis infectious?

C Greenfield, A Burroughs, M Szawathowski

    Lancet (London, England)
    |February 14, 1981
    PubMed
    Summary
    This summary is machine-generated.

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    A hospital outbreak of acute diarrhea was linked to Clostridium difficile infection. Prompt isolation and vancomycin treatment were effective, highlighting the need for strict precautions against this infectious colitis.

    Area of Science:

    • Infectious Diseases
    • Gastroenterology
    • Hospital Epidemiology

    Background:

    • Clostridium difficile infection (CDI) is a significant cause of hospital-acquired diarrhea.
    • Pseudomembranous colitis (PMC) is a severe manifestation of CDI.
    • Understanding transmission dynamics is crucial for infection control.

    Purpose of the Study:

    • To investigate a cluster of acute diarrhea cases in a hospital setting.
    • To identify the causative agent and clinical presentation.
    • To evaluate the effectiveness of treatment and recommend control measures.

    Main Methods:

    • Retrospective review of eight patients with acute diarrhea in adjacent hospital wards.
    • Stool sample analysis for Clostridium difficile toxin and bacterial isolation.

    Related Experiment Videos

  • Rectal biopsy examination for patients with severe symptoms.

    • Main Results:

    • Eight patients developed acute diarrhea within 11 days.
    • All stool samples tested positive for Clostridium difficile toxin and the bacteria.
    • Three patients showed rectal biopsy findings consistent with pseudomembranous colitis.
    • All patients responded well to oral vancomycin treatment.

    Conclusions:

    • The outbreak was attributed to Clostridium difficile infection.
    • Oral vancomycin proved effective in treating the affected patients.
    • Strict enteric precautions and isolation of patients are recommended to prevent cross-infection.