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Peptides and thermoregulation.

S Yehuda, A J Kastin

    Neuroscience and Biobehavioral Reviews
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Several peptides influence body temperature regulation, interacting with drugs like d-amphetamine. Ambient temperature and administration route significantly modify these peptide effects on thermoregulation.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Physiology

    Background:

    • Thermoregulation is a complex physiological process influenced by various endogenous and exogenous factors.
    • Several neuropeptides, including beta-endorphin, bombesin, and thyrotropin-releasing hormone (TRH), are recognized for their roles in modulating body temperature.
    • The interaction between these peptides and known thermoregulatory drugs, such as d-amphetamine, is an area of ongoing research.

    Purpose of the Study:

    • To review the known effects of various peptides on thermoregulation.
    • To explore the interactions between these peptides and thermoregulatory drugs like d-amphetamine.
    • To identify key variables that modify peptide-induced thermoregulatory effects.

    Main Methods:

    • Literature review of studies investigating peptide effects on body temperature.

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  • Comparative analysis of peptide and drug (e.g., morphine, naloxone) effects on thermoregulation.
  • Examination of how environmental factors and administration routes influence peptide actions.

    • Main Results:

    • Multiple peptides, including beta-endorphin, bombesin, MIF-I, alpha-MSH, neurotensin, TRH, and DSIP, affect thermoregulation.
    • Interactions between these peptides and d-amphetamine's thermal effects have been observed.
    • Comparisons highlight similarities between beta-endorphin and morphine, and naloxone and MIF-I regarding body temperature effects.
    • Ambient temperature and route of administration are critical variables modulating peptide-induced thermoregulation.

    Conclusions:

    • Peptides play a significant role in the complex system of thermoregulation.
    • Environmental conditions and drug administration methods are crucial factors influencing the outcome of peptide-based thermoregulatory interventions.
    • Further research is warranted to fully elucidate the mechanisms underlying peptide-drug interactions in thermoregulation.