Heparin-induced release of plasminogen activator

The influence of heparin and heparinoids on the release of plasminogen activator was studied in the isolated perfused pig ear. Heparin enhances the release of the tissue activator of fibrinolysis in a dose-dependent manner within the range of 0.05-1.0 IU/ml perfusion fluid. The release is also caused by sulfated polyanions at concentration of 10 microgram/ml.