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Copper deficiency in humans.

D M Danks

    Ciba Foundation Symposium
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Mild copper deficiency, characterized by anemia and bone changes, is a growing concern due to dietary shifts and medical treatments. Measuring serum caeruloplasmin levels can help detect this nutritional issue.

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    Area of Science:

    • Nutritional Science
    • Biochemistry

    Background:

    • Copper deficiency is a recognized nutritional problem in Peru and can occur in premature infants and adults undergoing specific medical treatments.
    • Decreasing copper intake in Western countries due to food processing may lead to widespread, low-grade chronic deficiency.
    • Menkes' syndrome highlights human susceptibility to vascular and neurological damage from copper deficiency.

    Purpose of the Study:

    • To identify and discuss the clinical manifestations and potential causes of copper deficiency.
    • To propose a method for detecting mild copper deficiency.

    Main Methods:

    • Review of clinical cases and known effects of copper deficiency.
    • Proposal of measuring serum caeruloplasmin concentrations before and after copper repletion as a diagnostic tool.

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    Main Results:

    • Copper deficiency can cause anemia, osteoporosis, and scurvy-like bone changes, all responsive to copper supplementation.
    • Mild, chronic copper deficiency may lead to significant vascular and neurological effects.

    Conclusions:

    • Mild copper deficiency is an emerging health concern with potential for serious vascular and neurological consequences.
    • Serum caeruloplasmin measurement is a suggested method for diagnosing mild copper deficiency.