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Updated: Aug 7, 2026

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Published on: August 18, 2008
Benzodiazepines modify the agonist responses at a presynaptic GABA receptor
Abstract:
The stimulus-induced release of [3H]glutamic acid from striatal tissue was actively modulated by a presynaptic GABA receptor. The agonist responses of this GABA receptor were modified stereoselectively by benzodiazepines at low concentrations. The results correlate well with effects seen in [3H]GABA binding experiments and as they demonstrate benzodiazepine-induced changes in GABA receptor properties in a tissue prism preparation, these results suggest that the mechanisms described for extensively disrupted preparations may also apply to whole tissue.
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