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LH-RH agonists and antagonists.

A V Schally, D H Coy, A Arimura

    International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
    |January 1, 1980
    PubMed
    Summary
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    Paradoxical antifertility effects from large doses of luteinizing hormone-releasing hormone (LH-RH) analogues are being explored for new contraceptives. Inhibitory LH-RH analogues show promise for birth control, potentially as a nasal spray with fewer side effects.

    Area of Science:

    • Reproductive endocrinology and pharmacology.

    Background:

    • Stimulatory analogues of luteinizing hormone-releasing hormone (LH-RH) can induce paradoxical antifertility effects.
    • These observed effects present a potential avenue for developing novel contraceptive strategies.

    Purpose of the Study:

    • To explore the feasibility of utilizing LH-RH analogues for contraceptive development.
    • To investigate the efficacy and potential application of inhibitory LH-RH analogues.

    Main Methods:

    • Administration of large doses of stimulatory LH-RH analogues.
    • Testing of several synthetic inhibitory analogues of LH-RH in both men and women.

    Main Results:

    • Large doses of stimulatory LH-RH analogues demonstrated antifertility effects.
    • Inhibitory LH-RH analogues were found to be active in human subjects.
    Keywords:
    BiologyContraceptionContraception ResearchEndocrine SystemFamily PlanningFemale ContraceptionGonadotropinsHormone Antagonists--analysisHormonesLiterature ReviewMale ContraceptionPhysiologyPituitary Hormone Releasing Hormones--analysis

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    Conclusions:

    • The synthetic approach using inhibitory LH-RH analogues is a viable strategy for new birth control methods.
    • Further research may lead to the development of convenient nasal spray contraceptives based on inhibitory LH-RH analogues, potentially with reduced side effects.