The assay of pseudoephedrine hydrochloride in tablets and liquid formulations by two phase acid-base titration

A novel titration method for the assay of pseudoephedrine hydrochloride in formulations is presented. Pseudoephedrine base is extracted into chloroform and titrated with acid in a two phase system. The method is specific for the drug in tablet and syrup formulations. The precision and speed of assay are comparable with existing spectrometric and titration methods for amine drugs.