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Updated: Aug 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
[Nicotinic acid effect on acetyl-CoA-carboxylic activity in chicken liver]
Abstract:
Changes of acetyl-CoA-carboxylase (EC 6.4.1.2) activity and the NAD content in the liver tissue were studied in dynamics after excessive administration of nicotinic acid to chickens. It is established that in chickens, which were given a high-carbohydrate diet after fasting, administration of nicotinic acid at first causes a fall of the acetyl-CoA-activity in the liver tissue, followed by its gradual rise against a background of the NAD content drop and by the 24th hour its level approaches the initial values. The maxima of NAD accumulation and of the acetyl-CoA-carboxylase activity decrease coincide in time. The administration of nicotinic acid to these chickens causes both a decrease in the intensity of 2-14C acetate incorporation into free fatty acids and a drop in their content.
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