The effect of triazole on RNA viruses

The triazole derivative 4-(1-hydroxy-3-piperid-N-yl-prop-l-yl)-5-methyl-2-methyl-2-phenyl-triazole (HMPT) markedly reduced plaque formation by, RNA bacteriophages and delayed their liberation. Replication of tobacco mosaic virus in a systemic host was hardly affected by HMPT, but local lesion formation in a hypersensitive host was strongly reduced by the drug. The mechanism of action of HMPT was discussed.