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Related Experiment Videos

Tritiated LSD binding in frontal cortex in schizophrenia.

P M Whitaker, T J Crow, I N Ferrier

    Archives of General Psychiatry
    |March 1, 1981
    PubMed
    Summary

    This study found no reduction in serotonin receptor binding in schizophrenic brains, challenging previous findings. Neuroleptic medication may explain earlier results, with increased binding observed in drug-free patients.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Previous research suggested reduced serotonin receptor binding in schizophrenia.
    • This interpretation was based on tritiated LSD binding studies in the frontal cortex.
    • Potential confounding factors like residual neuroleptic medication were not fully addressed.

    Purpose of the Study:

    • To re-evaluate tritiated LSD binding in the frontal cortex of schizophrenic patients.
    • To investigate the influence of neuroleptic medication on LSD binding.
    • To clarify the status of serotonin receptors in schizophrenia.

    Main Methods:

    • Scatchard analysis of tritiated LSD binding in the frontal cortex of 13 schizophrenic patients and 8 control brains.
    • Comparison of binding characteristics between patient and control groups.
    • Investigation of LSD binding in brains of patients with documented neuroleptic-free periods.

    Main Results:

    • No significant decrease in tritiated LSD binding was observed in schizophrenic brains compared to controls.
    • Residual neuroleptic medication was identified as a potential confounder affecting previous findings.
    • Significantly increased tritiated LSD binding was found in the brains of five neuroleptic-free schizophrenic patients.

    Conclusions:

    • The study challenges the hypothesis of reduced serotonin receptor numbers in schizophrenia.
    • Neuroleptic medication may artificially lower observed LSD binding.
    • Further research with larger samples is needed to confirm increased LSD binding in neuroleptic-free schizophrenic patients.

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