Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Somatostatin. I: Structure, biosynthesis and effect].

H Zühlke, B Ziegler, K P Ratzmann

    Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
    |January 15, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Factors associated with cystic fibrosis mortality before the age of 30: retrospective analysis of a cohort in southern Brazil.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2024
    Same author

    Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2023
    Same author

    [Anesthesiological aspects in patients with epidermolysis bullosa].

    Die Anaesthesiologie·2022
    Same author

    Random-pattern versus perforator-based adipocutaneous skin paddles for postoperative monitoring of free muscle flaps-a comparative retrospective cohort study.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2020
    Same author

    Functional capacity, lung function, and muscle strength in patients undergoing hematopoietic stem cell transplantation: A prospective cohort study.

    Hematology/oncology and stem cell therapy·2020
    Same author

    A prospective observational study of the rapid detection of clinically-relevant plasma direct oral anticoagulant levels following acute traumatic injury.

    Anaesthesia·2020
    Same journal

    [Report on the Fifth International Congress on Blood Transfusion, Paris, 13 to 19 September 1954].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation; literature from 1952 to 1954. VI].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation; publications from 1952-1954. V].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Blood coagulation from 1952-1954. IV].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [Report on the fourth congress of the European Gastroenterological Society in Paris, 27 June to 2 July 1954].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    Same journal

    [The islands of Langerhans in pancreatic carcinoma].

    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete·2014
    See all related articles

    Somatostatin, produced by pancreatic D-cells, inhibits insulin and glucagon secretion. Analogs enhance its clinical potential by improving half-life and selectivity.

    Area of Science:

    • Endocrinology
    • Cell Biology
    • Molecular Biology

    Context:

    • Pancreatic islets contain specialized cells (A, B, D) responsible for hormone synthesis.
    • Somatostatin, synthesized in D-cells, plays a crucial role in regulating pancreatic hormone secretion.

    Purpose:

    • To elucidate the inhibitory role of somatostatin on insulin and glucagon.
    • To explore pancreatic cell differentiation and somatostatin's mechanism of action.
    • To assess the potential of somatostatin analogs for clinical applications.

    Summary:

    • Somatostatin is synthesized and stored in pancreatic islet D-cells.
    • It inhibits the secretion of insulin (from B-cells) and glucagon (from A-cells).
    • The study discusses pancreatic cell differentiation and somatostatin's mechanism, highlighting the use of analogs to improve its therapeutic efficacy.

    Related Experiment Videos

    Impact:

    • Understanding somatostatin's regulation of insulin and glucagon is vital for metabolic disease research.
    • Development of somatostatin analogs offers improved therapeutic strategies.
    • Enhanced selectivity and half-life of analogs increase clinical utility in managing endocrine disorders.