[Effectiveness of treating early-onset malignant schizophrenia with psychotropic drugs and their combinations]

The effectiveness of 1211 treatment courses given to 96 patients with "nuclear" schizophrenia was estimated by statistical methods with consideration of the therapy form (individual psychotropic drugs or their combinations) and the clinical variants of the disease. A number of statistically significant effects produced by these two factors and their interaction was revealed. The direction of the effects points to a relative advantage of the combined pharmacotherapy that envisages simultaneous use of drugs with different spectrum of action. In different variants of the disease, the efficacy of each of the 10 forms of the therapy was different: rather peculiar in this respect was the catatono-hebephrenic variant.