[Hemodynamic effects of hypotensive agents under adrenergic block in hypertension]

Examination of 94 patients with stage II hypertensive disease and 20 rabbits with hypertension showed that in the hypokinetic type of hemodynamics separate medication with dibazol, papaverin hydrochloride and reserpine caused a reduction of arterial pressure in all cases due to a decrease in total peripheral resistance. In combination with phentolamine dibazol and papaverin hydrochloride caused no further decrease of arterial pressure whereas the hypotensive effect of reserpine in this case was intensified along the type of summation of hypotensive effects due to more significant decrease in total peripheral resistance. During beta-adrenostructure blocking in patients with hyperkinetic type of hemodynamics, arterial pressure dropped due to a decrease of the cardiac output. Medication with dibazol, papaverin hydrochloride and reserpine during beta-adrenergic block led to more marked drop in arterial pressure because these agents prevented an increase of total peripheral resistance encountered when only beta-adrenergic blocking agents are given.