A dose response relation between improved lactation and metoclopramide

Area of Science:

• Obstetrics and Gynecology
• Lactation Physiology
• Pharmacology

Background:

• Inadequate breast milk production is a common concern for postpartum women.
• Effective and safe interventions to enhance lactation are crucial for maternal and infant well-being.

Purpose of the Study:

• To evaluate the efficacy of metoclopramide in improving breast milk secretion in puerperal women.
• To assess the effect of different metoclopramide dosages on maternal serum prolactin levels and milk yield.

Main Methods:

• A placebo-controlled, cross-over study involving thirty-seven postpartum women with insufficient milk production.
• Administration of metoclopramide at 5, 10, or 15 mg doses, three times daily for two weeks, compared to placebo.
• Measurement of maternal serum prolactin and breast milk volume per feed.

Main Results:

• Doses of 10 and 15 mg of metoclopramide significantly increased maternal serum prolactin and breast milk secretion.
• Milk yield increased by 42.5 ml and 50.0 ml per feed with 10 mg and 15 mg doses, respectively.
• A reduced need for supplementary feeds was observed, with 33% of infants requiring none during treatment; 5 mg doses were ineffective.

Conclusions:

• Metoclopramide, particularly at 10 and 15 mg doses, is effective in enhancing breast milk production.
• The therapy shows potential for improving lactation in mothers with inadequate milk supply, with a favorable subjective response and minimal side effects.
• No adverse effects were noted in infants, suggesting a favorable safety profile.