Related Experiment Videos
Salmonella typhi in vivo acquires resistance to both chloramphenicol and co-trimoxazole
Lancet (London, England)
|May 30, 1981
Abstract:
Salmonella typhi in the bowel of a patient with enteric fever treated with chloramphenicol and later co-trimoxazole acquired resistance to these drugs. Chloramphenicol and sulphonamide resistances were determined by one plasmid, of IncH, whose carriage also changed the Vi phage type. Trimethoprim resistance was determined by a transposon, Tn7, carried in another plasmid, of IncI. The same resistance genes were identified in a strain of klebsiella isolated from the patient.
Insights
Salmonella typhi developed resistance to chloramphenicol and co-trimoxazole due to plasmids and transposons. These genetic elements, carrying resistance genes, were also found in a Klebsiella strain from the same patient.
Area of Science:
- Microbiology
- Molecular Biology
- Genetics
Background:
- Enteric fever, caused by Salmonella typhi, is a significant public health concern.
- Antimicrobial resistance in Salmonella typhi poses a therapeutic challenge.
- Previous studies have indicated the role of plasmids in antimicrobial resistance.