Immunohistochemical localization of guanylate cyclase in rat cerebellum

The localization of guanylate cyclase has been studied in rat cerebellum by indirect immunoperoxidase and immunofluorescence techniques. The study showed staining in all neuronal cells (stellate neurones, Purkinje, Golgi and granule cells) and in all glial cells (astrocytes and oligodendrocytes). This wide distribution of guanylate cyclase contrasts with the distribution of cyclic GMP previously demonstrated biochemically or immunohistologically.