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Oral anti-microbial prophylaxis in colonic surgery
Aktuelle Probleme in Chirurgie Und Orthopadie
|January 1, 1981
Summary
Preoperative oral kanamycin and metronidazole for 3 days effectively reduce aerobic and anaerobic gut bacteria, lowering surgical wound infection rates. This safe regimen showed no adverse effects over six years.
Area of Science:
- Surgical prophylaxis
- Microbiology
- Infectious disease
Background:
- Postoperative wound infections are a significant complication in colorectal surgery.
- Suppression of colonic microflora is a key strategy to prevent surgical site infections.
Purpose of the Study:
- To evaluate the efficacy of a 3-day preoperative oral antibiotic regimen in suppressing colonic microflora.
- To determine the impact of this regimen on the incidence of postoperative wound infections.
Main Methods:
- Oral administration of kanamycin and metronidazole for 3 days prior to surgery.
- Monitoring of aerobic and anaerobic colonic microflora.
- Assessment of postoperative wound infection rates over a 6-year period.
Main Results:
- Significant suppression of both aerobic and anaerobic colonic microflora was achieved.
- A significant reduction in the incidence of postoperative wound infections was observed.
- No toxic or untoward effects were reported during the 6-year study period.
Conclusions:
- A 3-day preoperative oral antibiotic combination of kanamycin and metronidazole is effective in reducing colonic microflora.
- This regimen significantly lowers the risk of postoperative wound infections.
- The antibiotic combination demonstrates a favorable safety profile with no observed adverse effects.