The identification of functioning plasma cells in cervical tissue by an immunoperoxidase technique

The detection of sperm agglutinating antibodies in the blood has become a basic screening test for the infertility workup. However, documentation of these antibodies in the cervical mucus has been variable because procurement and preparation of this genital secretion is often difficult. In this report the local immune response has been examined in cervical tissue instead of mucus. A small biopsy was taken from the endo- and ectocervix and treated by an immunoperoxidase technique. Functioning plasma cells were clearly identified. This technique may be adaptable for clinical practice as part of the evaluation of immune infertility.