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Effect of medroxyprogesterone acetate contraception on human serum enzymes
International Journal of Fertility
|January 1, 1981
Abstract:
Activities of five enzymes were determined biochemically in the serum of a woman taking the injectable contraceptive, depo-medroxyprogesterone acetate (DMPA), 150 mg every 3 months for 2 years. The specific activities of SGOT, SGPT, and alkaline phosphatase (AP)-the enzymes commonly discerned in tests on the function of the liver-do not show any change with long-term treatment of this steroid contraceptive. Activities of serum acid phosphatase (ACP) and acetylcholinesterase (AChE) in red cells show significant increase. DMPA contraception has no apparent harmful effect on liver function, although the rise in ACP and AChE activities may be related to some pathological condition.
Keywords:
AsiaBiologyClinical ResearchContraceptionContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--side effectsContraceptive Agents--side effectsDeveloping CountriesEnzymatic EffectsEnzymes And Enzyme InhibitorsFamily PlanningFollow-up StudiesHepatic EffectsHuman VolunteersIndiaInjectablesMedroxyprogesterone Acetate--side effectsPhysiologyResearch MethodologySouthern AsiaStudies