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[Midazolam in preoperative sleep].

N Cadi, Y Jullien, O Griffe

    Annales De L'Anesthesiologie Francaise
    |January 1, 1981
    PubMed
    Summary
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    This study compared oral midazolam to meprobamate and placebo for hypnotic effects in surgical patients. Midazolam demonstrated significant hypnotic properties, offering a potential pre-operative sedative option.

    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Sleep Medicine

    Background:

    • Pre-operative anxiety and sleep disturbances are common in surgical patients.
    • Effective and safe hypnotic agents are crucial for patient management before surgery.

    Purpose of the Study:

    • To evaluate the hypnotic effects of orally administered midazolam.
    • To compare midazolam's efficacy against meprobamate and a placebo in a surgical patient population.

    Main Methods:

    • A double-placebo, parallel-group study design was employed.
    • 83 patients (18-60 years) undergoing maxillofacial or gynecological surgery received single doses of midazolam (15 mg), meprobamate (250 mg), or placebo.
    • Sleep and awakening variables, including onset, duration, quality, and post-awakening state, were assessed.

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    Main Results:

    • Midazolam (15 mg) administered per os showed significant hypnotic effects.
    • The study assessed 29 variables related to sleep and awakening in surgical patients.
    • Comparison was made between midazolam, meprobamate (250 mg), and placebo groups.

    Conclusions:

    • Oral midazolam exhibits notable hypnotic properties in patients awaiting surgery.
    • Midazolam presents a viable alternative for pre-operative sedation, warranting further clinical investigation.