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Related Experiment Videos

Cold urticaria with persistent weals.

L Juhlin

    The British Journal of Dermatology
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Cold urticaria patients experienced prolonged swelling after ice cube exposure. Pre-treatment with antihistamines prevented this delayed reaction, suggesting a crucial role for immediate histamine release.

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    Area of Science:

    • Dermatology
    • Immunology
    • Allergy

    Background:

    • Cold urticaria is a condition causing hives upon cold exposure.
    • Understanding the mechanisms behind cold urticaria is crucial for effective treatment.

    Observation:

    • A patient presented with immediate wealing after a 3-minute ice cube test.
    • This reaction evolved into a week-long red, tender swelling (edema).
    • The duration of edema correlated with the severity of the initial hive reaction.

    Findings:

    • Blocking the immediate reaction with an oral antihistamine 3 hours prior prevented the delayed swelling.
    • Administering antihistamines after the initial hives appeared did not affect the subsequent edema.
    • Reactions to intradermal injections of histamine, prostaglandin E, kallikrein, serotonin, and serum were within normal limits.

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    Implications:

    • This case highlights the critical role of the immediate histamine release in the pathogenesis of cold urticaria.
    • Prophylactic antihistamine treatment is effective in preventing prolonged cold-induced swelling.
    • Further research into the temporal relationship between immediate and delayed reactions in cold urticaria is warranted.