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The APUD system and its apudomas.

W J Temple, E V Sugarbaker, A S Ketcham

    International Advances in Surgical Oncology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    The APUD (Amine Precursor Uptake and Decarboxylation) system comprises interrelated endocrine cells with common features. Research has expanded understanding of APUD cell origins, physiology, classification, and associated apudomas.

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    Area of Science:

    • Endocrinology
    • Cell Biology
    • Histology

    Background:

    • The discovery of the APUD system, characterized by amine precursor uptake and decarboxylation, has revolutionized endocrinology.
    • This system's cells, though anatomically dispersed, share biosynthetic, histochemical, ultrastructural, and embryologic origins.
    • The APUD acronym reflects the cells' capacity for Amine Precursor Uptake and Decarboxylation, leading to bioactive amine or polypeptide hormone synthesis.

    Purpose of the Study:

    • To review recent advancements in understanding the APUD system.
    • To synthesize current knowledge on the origin, diagnosis, and treatment of apudomas.
    • To incorporate newly identified APUD cell members into the existing classification.

    Main Methods:

    • Review of current research on the APUD system.

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  • Synthesis of data on apudoma characteristics.
  • Analysis of embryologic origins and physiological interrelationships.

    • Main Results:

    • Significant research has refined original concepts of the APUD system.
    • The classification, embryologic origin, and physiological interrelationships have been updated.
    • New APUD cell members have been identified, expanding the system's scope.

    Conclusions:

    • The APUD system represents a significant conceptual advance in endocrinology.
    • Continued research is crucial for a comprehensive understanding of APUD cells and apudomas.
    • The integrated review provides a foundation for future diagnostic and therapeutic strategies.