Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis

Histomorphometry has been applied to trabecular bone samples obtained post-mortem from young and old women without known bone disease and to bone biopsy specimens from patients with postmenopausal osteoporosis. Bone volume was significantly lower in the old than young controls and significantly lower again in the osteoporotics. The loss of bone with age associated with a rise in surface resorption but no change in forming surface, and the further loss in osteoporotics was associated with a further rise in resorption and a small non-significant fall in forming surfaces. It is suggested that trabecular bone volume is determined by the relation between total forming surface on the one hand and percent surface resorption on the other, and this relationship is expressed in mathematical terms. Age-related bone loss (simple osteoporosis) in women is accounted for by increased resorption, and accelerated osteoporosis is mainly due to a further increase in resorption.