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Related Experiment Videos

APUD cells in teratomas.

F T Bosman, J W Louwerens

    The American Journal of Pathology
    |August 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    The origin of amine precursor uptake and decarboxylation (APUD) cells in the respiratory and gastrointestinal tracts was investigated. APUD cells in teratomas suggest a direct endodermal origin, not from neural crest cells.

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    Area of Science:

    • Developmental biology
    • Endocrinology
    • Histology

    Background:

    • The origin of endocrine cells in the respiratory and gastrointestinal tracts is debated.
    • The amine precursor uptake and decarboxylation (APUD) system concept initially proposed a neural crest origin.
    • Recent hypotheses suggest neuroendocrine-programmed ectoblast or direct endodermal origin.

    Purpose of the Study:

    • To investigate the origin of APUD cells in the respiratory and gastrointestinal tracts.
    • To examine teratomas (ovarian and testicular) for the presence of brain tissue and APUD cells.
    • To determine if APUD cell differentiation in teratomas supports a specific embryogenic origin.

    Main Methods:

    • Analysis of cystic ovarian teratomas and testicular teratocarcinomas.

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  • Histological examination for brain tissue and various APUD cell types.
  • Detection of peptide hormone production in relevant tissues.

    • Main Results:

    • Ovarian teratomas contained intestinal and respiratory APUD cells without brain tissue.
    • Melanocytes, of neuroectodermal origin, were found with brain tissue in ovarian teratomas.
    • Testicular teratocarcinomas showed intestinal APUD cells, also without brain tissue. Peptide hormone production was confirmed.

    Conclusions:

    • Findings suggest that intestinal and respiratory APUD cells differentiate within teratomas.
    • These APUD cells likely descend directly from intestinal and respiratory epithelium.
    • This supports a direct endodermal origin for these endocrine cell types, challenging neural crest or ectoblast origins.