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Related Experiment Videos

Bacterial adherence to cell surface sugars.

N Sharon, Y Eshdat, F J Silverblatt

    Ciba Foundation Symposium
    |January 1, 1981
    PubMed
    Summary
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    Bacterial adherence to host cells, often mediated by sugars like D-mannose, is key to infection. Inhibiting this sugar-mediated adherence could prevent bacterial infections.

    Area of Science:

    • Microbiology
    • Cell Biology
    • Immunology

    Background:

    • Bacterial adherence to host cells is crucial for pathogenicity and understanding cell recognition.
    • Sugar-mediated adherence, involving specific sugars like D-mannose, L-fucose, and D-galactose, is a widespread mechanism for bacterial attachment.

    Purpose of the Study:

    • To explore the role of sugar-mediated bacterial adherence in host-pathogen interactions.
    • To investigate the potential of targeting sugar-binding mechanisms for preventing bacterial infections.

    Main Methods:

    • Investigated the inhibitory effects of various sugars (D-mannose, L-fucose, D-galactose) on bacterial adherence to animal cells.
    • Examined the role of bacterial lectin-like substances, such as pili, in sugar-specific attachment.
    • Assessed the in vivo efficacy of a mannose derivative in reducing Escherichia coli infections in mice.

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    Main Results:

    • D-mannose significantly inhibited the adherence of Escherichia coli and Salmonella spp. to epithelial cells and phagocytes.
    • Mannose-specific bacterial attachment, mediated by lectins like pili, appears to facilitate host colonization.
    • Methyl alpha-D-mannoside reduced urinary tract infections in mice caused by virulent E. coli strains.

    Conclusions:

    • Sugar-mediated adherence is a significant factor in bacterial pathogenicity.
    • Targeting bacterial sugar-binding mechanisms, particularly mannose-specific adherence, offers a promising strategy for developing novel anti-adherence therapies to combat bacterial infections.