Effects of edeine, hygromycin B and alpha-Sarcin on influenza virus reproduction

The effects of edeine, hygromycin B and alpha-sarcin on the synthesis of virus-specific proteins and formation of infectious virions was studied in cells infected with fowl plague virus (FPV). The manifestation of the antiviral effect of edeine depended on the peculiarities of the FPV strains and the host-cell systems. Hygromycin B inhibited significantly the synthesis of virus-specific proteins and the formation of the infectious virions, but did not influence protein synthesis in uninfected cells. Alpha-Sarcin in the concentrations tested neither showed a marked antiviral activity nor affected protein synthesis in the uninfected cells.