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Hypothalamic peptides: central nervous system control of visceral functions
Federation Proceedings
|September 1, 1981
Summary
Thyrotropin-releasing factor (TRF), somatostatin, and bombesin influence thermoregulation and visceral functions via the central nervous system. These brain peptides modulate autonomic outflow, affecting hormone secretion and physiological responses.
Area of Science:
- Neuroendocrinology
- Autonomic Nervous System Regulation
- Physiological Control Systems
Background:
- Brain peptides like TRF, somatostatin, and bombesin are implicated in central nervous system (CNS) control of visceral functions.
- These neurochemicals are known to influence thermoregulation in animals.
Purpose of the Study:
- To investigate the role of TRF, somatostatin, and bombesin in the CNS control of visceral functions.
- To elucidate the specific effects of these peptides on autonomic outflow and physiological responses.
Main Methods:
- Administration of TRF, somatostatin, and bombesin within the brain.
- Monitoring of autonomic outflow (parasympathetic and sympathetic).
- Measurement of physiological parameters including adrenal epinephrine secretion, gastric acid secretion, heart rate, and blood pressure.
Main Results:
- TRF and somatostatin modulate both parasympathetic and sympathetic outflow, impacting adrenal epinephrine, gastric acid secretion, heart rate, and blood pressure.
- Bombesin increases adrenal epinephrine secretion and inhibits gastric acid secretion, with minimal impact on other autonomic activities.
- All three peptides demonstrate potent actions on animal thermoregulation.
Conclusions:
- TRF, somatostatin, and bombesin are key regulators of CNS control over visceral systems.
- These peptides play significant roles in processing CNS information related to thermoregulation and autonomic functions.
- Further research into these peptides may reveal important physiological regulatory mechanisms.